A practical metal-free homolytic aromatic alkylation protocol for the synthesis of 3-(pyrazin-2-yl)bicyclo[1.1.1]pentane-1-carboxylic acid.
نویسندگان
چکیده
As a part of our ongoing synthetic quest to expand the frontiers of contemporary medicinal chemistry, we now report an expedient synthesis of a potentially useful bicyclo[1.1.1]pentane building block, 3-(pyrazin-2-yl)bicyclo[1.1.1]pentane-1-carboxylic acid. This report also showcases the application of this motif as a probe in a biological study.
منابع مشابه
1,3-Bicyclo ACHTUNGTRENNUNG[1.1.1]pentanediyl: The Shortest Rigid Linear Connector of Phenylated Photochromic Units and a 1,5-Dimethoxy-9,10- di(phenylethynyl)anthracene Fluorophore
BicycloACHTUNGTRENNUNG[1.1.1]pentane and its derivatives are not only of theoretical interest, but have attracted particular attention of organic and physical-organic chemists as peculiar fragments in oligomers, liquid crystalline compounds, supramolecular aggregates and monolayers, as well as compounds for drug design, etc. 1,3-Disubstituted derivatives—bicycloACHTUNGTRENNUNG[1.1.1]pentanes wi...
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 14 40 شماره
صفحات -
تاریخ انتشار 2016